Across TCGA cell cohorts, IFT140 mutation is significantly associated with the mutation status of many other genes, with 6,344 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFT140-associated genes across cancer lineages are SACS, XIRP2, and ZFP64. Each is linked with IFT140 in more than 5 cancer types. Because this analysis shows association rather than direction, both IFT140-to-partner and partner-to-IFT140 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT140→partner) and Y-score (partner→IFT140) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SACS →	+2.678	+3.652	.006	.006	1	6
CNS	XIRP2 →	+2.614	+4.121	.009	.009	1	5
BLOOD_Leukemia	ZFP64 →	+3.111	+2.762	<.001	<.001	1	5
LUNG_NSCLC_LUAD	ACAN →	+2.670	+3.165	.004	.004	1	5
BLOOD_Leukemia	NLRP3 →	+3.847	+2.825	.001	.001	1	4
LARGE_INTESTINE	FCGBP →	+2.695	+2.862	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,344 associations by consensus.

Exploration

IFT140 survival (RNA) · tumor vs normal (RNA) · all IFT140 data types