IFT122

Across TCGA cell cohorts, IFT122 mutation is significantly associated with the RNA expression of many other genes, with 645 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFT122-associated genes across cancer lineages are SSMEM1, TRMU, and ADNP2. Each is linked with IFT122 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFT122-to-partner and partner-to-IFT122 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by IFT122-low versus IFT122-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFT122→partner) and Y-score (partner→IFT122) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.017	+2.193	.005	.004	3	3
LARGE_INTESTINE	TRMU →	+0.689	+3.169	<.001	.009	3	2
LARGE_INTESTINE	ADNP2 →	+0.903	+3.502	<.001	.001	3	2
LARGE_INTESTINE	MYH3 →	+0.621	+3.064	.001	.009	3	2
LARGE_INTESTINE	TTK →	+0.529	+3.502	.008	.001	3	2
LARGE_INTESTINE	SMNDC1 →	+0.529	+3.169	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 645 associations by consensus.

SSMEM1 by IFT122 expression — LARGE_INTESTINE

Explore this box plot interactively →