IFRD1

Across TCGA patient cohorts, IFRD1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFRD1-associated genes across cancer lineages are p21, EGFR_pY1068, and A-Raf_pS299. Each is linked with IFRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFRD1-to-partner and partner-to-IFRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by IFRD1-low versus IFRD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFRD1→partner) and Y-score (partner→IFRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.146	+2.598	.035	.005	3	2
UCEC	EGFR_pY1068 →	-0.307	-2.321	<.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.135	-1.700	.001	.042	3	1
UCEC	FASN →	+0.308	+2.000	.030	.030	3	1
UCEC	FOXO3a_pS318_S321 →	-0.110	-1.575	.014	.034	3	1
UCEC	ACC1 →	+0.315	+1.887	.015	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p21 by IFRD1 expression — UCEC

Explore this box plot interactively →