IFRD1

Across TCGA pan-cancer cohorts, IFRD1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IFRD1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IFRD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFRD1 is over-expressed in tumor, although a few such as BRCA and PAAD show the opposite, repressed pattern.

KIRC, LIHC, and BRCA are the cancer types where IFRD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFRD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.045	<.001	11	view →
LIHC	Male	II,III,IV	+1.058	<.001	8	view →
BRCA	All	III,IV	−1.012	<.001	8	view →
KIRP	Female	All	+0.882	.006	8	view →
HNSC	All	III,IV	+0.632	<.001	8	view →
COAD	Male	II,III,IV	+0.784	<.001	7	view →
UCEC	All	II,III,IV	+0.698	.024	4	view →
CHOL	Male	All	+1.871	<.001	3	view →
LUAD	All	IV	+1.674	.004	2	view →
KICH	All	IV	+1.245	.039	2	view →
PAAD	All	All	−0.292	.009	2	view →
STAD	Male	II,III,IV	+0.547	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IFRD1–KIRC

Open the KIRC breakdown →