IFRD1

Across TCGA cell cohorts, IFRD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,775 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IFRD1-associated GO terms across cancer lineages are Regulation of telomeric D-loop disassembly, Myoblast fate commitment, and PERK-mediated unfolded protein response. Each is linked with IFRD1 in more than 10 cancer types. Because this analysis shows association rather than direction, both IFRD1-to-partner and partner-to-IFRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomeric D-loop disassembly grouped by IFRD1-low versus IFRD1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFRD1→partner) and Y-score (partner→IFRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of telomeric D-loop disassembly →	+0.091	+1.257	<.001	<.001	3	11
BLOOD_Lymphoma	Myoblast fate commitment →	+0.215	+0.768	<.001	<.001	3	11
BLOOD_Lymphoma	PERK-mediated unfolded protein response →	+0.099	+1.062	<.001	<.001	3	11
BONE	Cytosolic ribosome assembly →	+0.088	+0.926	<.001	.007	3	10
LARGE_INTESTINE	L-serine biosynthetic process →	+0.161	+0.745	<.001	.006	3	9
STOMACH	Pyrimidine nucleoside triphosphate catabolic process →	-0.093	-0.993	.006	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,775 associations by consensus.

Regulation of telomeric D-loop disassembly by IFRD1 expression — KIDNEY

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