IFRD1

Across TCGA cell cohorts, IFRD1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IFRD1-associated genes across cancer lineages are ADAD1, GPR101, and LILRB5. Each is linked with IFRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFRD1-to-partner and partner-to-IFRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAD1 grouped by IFRD1-low versus IFRD1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFRD1→partner) and Y-score (partner→IFRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ADAD1 →	+0.008	+4.392	<.001	.004	3	2
SOFT_TISSUE	GPR101 →	+0.008	+3.882	.003	.004	3	2
SOFT_TISSUE	LILRB5 →	+0.096	+3.736	<.001	.008	3	1
SOFT_TISSUE	RIT2 →	+0.404	+4.169	<.001	.002	3	1
SOFT_TISSUE	CD1B →	+0.050	+3.635	<.001	.007	3	1
SOFT_TISSUE	CD3G →	+0.081	+4.142	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ADAD1 by IFRD1 expression — SOFT_TISSUE

Explore this box plot interactively →