IFNL4

Across TCGA cell cohorts, IFNL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 290 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IFNL4-associated GO terms across cancer lineages are Regulation by virus of viral protein levels in host cell, Icosanoid transport, and Regulation of viral life cycle. Each is linked with IFNL4 in more than 4 cancer types. Because this analysis shows association rather than direction, both IFNL4-to-partner and partner-to-IFNL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation by virus of viral protein levels in host cell grouped by IFNL4-low versus IFNL4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNL4→partner) and Y-score (partner→IFNL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation by virus of viral protein levels in host cell →	+0.172	+0.006	<.001	.009	3	5
BLOOD_Lymphoma	Icosanoid transport →	-0.077	-0.007	.004	.006	3	4
LARGE_INTESTINE	Regulation of viral life cycle →	+0.147	+0.007	<.001	.007	3	4
BLOOD_Lymphoma	Negative regulation of gliogenesis →	+0.077	+0.014	.006	.005	3	3
BLOOD_Lymphoma	Mitochondrion-endoplasmic reticulum membrane tethering →	+0.130	+0.008	<.001	.003	3	3
BLOOD_Lymphoma	Regulation of tumor necrosis factor production →	+0.057	+0.007	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 290 associations by consensus.

Regulation by virus of viral protein levels in host cell by IFNL4 expression — LARGE_INTESTINE

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