IFNL4

Across TCGA pan-cancer cohorts, IFNL4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IFNL4 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher IFNL4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IFNL4 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

LIHC, LUSC, and OV are the cancer types where IFNL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.511	0.714	<.001	81	view →
LUSC	DFS	Median	All	0.283	0.468	<.001	63	view →
OV	OS	Median	All	0.792	0.886	.005	58	view →
UCS	DFS	Tertile	III,IV	0.718	0.180	<.001	56	view →
UCEC	OS	Quartile	All	0.563	0.733	.001	50	view →
PAAD	DFS	Tertile	III,IV	0.275	0.794	.008	42	view →
HNSC	DFS	Tertile	All	0.442	0.299	.010	27	view →
BLCA	DFS	Tertile	All	0.234	0.385	.016	23	view →
SKCM	DFS	Median	III,IV	0.384	0.168	.003	22	view →
STAD	OS	Median	III,IV	0.610	0.356	.011	10	view →
DLBC	OS	Tertile	II,III,IV	0.640	1.000	.019	9	view →
ACC	DFS	Tertile	III,IV	0.069	0.470	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IFNL4–LIHC (OS)

Open the LIHC breakdown →