Across TCGA patient cohorts, IFNL2 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNL2-associated genes across cancer lineages are CDH12P2, RNY4P14, and RNU1-4. Each is linked with IFNL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFNL2-to-partner and partner-to-IFNL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNL2→partner) and Y-score (partner→IFNL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDH12P2 →	+0.161	+7.228	<.001	<.001	3	3
CESC	RNY4P14 →	+0.436	+5.144	<.001	.003	3	1
CESC	RNU1-4 →	+0.190	+5.837	<.001	.001	3	1
CESC	MIR561 →	+0.571	+4.234	.003	.008	3	1
CESC	RNU6-1319P →	+0.330	+4.812	<.001	.006	3	1
CESC	SLC25A20P1 →	+0.061	+4.539	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Exploration

IFNL2 survival (RNA) · tumor vs normal (RNA) · all IFNL2 data types