IFNGR1

Across TCGA patient cohorts, IFNGR1 mutation is significantly associated with the RNA expression of many other genes, with 1,865 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNGR1-associated genes across cancer lineages are TRAJ57, RNA5SP417, and PSAT1P4. Each is linked with IFNGR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFNGR1-to-partner and partner-to-IFNGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ57 grouped by IFNGR1-low versus IFNGR1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNGR1→partner) and Y-score (partner→IFNGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRAJ57 →	+0.593	+5.230	<.001	.007	3	3
UCEC	RNA5SP417 →	+1.024	+3.673	<.001	<.001	3	2
CESC	PSAT1P4 →	+0.078	+3.333	<.001	.004	3	2
SKCM	SNORA51 →	+0.483	+3.878	.002	.002	3	2
LUAD	KCNK18 →	+0.053	+4.631	<.001	.008	3	2
LUAD	MIR4684 →	+0.423	+4.631	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,865 associations by consensus.

TRAJ57 by IFNGR1 expression — BRCA

Explore this box plot interactively →