IFNGR1

Across TCGA pan-cancer cohorts, IFNGR1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of IFNGR1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IFNGR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFNGR1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where IFNGR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFNGR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.815	<.001	12	view →
KIRC	Male	All	+1.042	<.001	11	view →
KICH	Female	II,III,IV	−1.441	<.001	10	view →
STAD	All	III,IV	+1.314	<.001	10	view →
LUAD	All	III,IV	−1.000	<.001	9	view →
UCEC	All	All	−1.191	<.001	8	view →
LUSC	Female	All	−1.211	<.001	7	view →
BRCA	All	III,IV	−0.966	<.001	6	view →
LIHC	Male	II,III,IV	+1.351	.001	5	view →
KIRP	All	All	+0.463	.002	4	view →
COAD	Female	All	−0.525	.009	3	view →
ESCA	All	All	+0.960	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

IFNGR1–HNSC

Open the HNSC breakdown →