IFNGR1

Across TCGA cell cohorts, IFNGR1 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFNGR1-associated genes across cancer lineages are S100A7A, HTR3D, and IFNL3. Each is linked with IFNGR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNGR1-to-partner and partner-to-IFNGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100A7A grouped by IFNGR1-low versus IFNGR1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNGR1→partner) and Y-score (partner→IFNGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	S100A7A →	+0.056	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	HTR3D →	+0.020	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	IFNL3 →	+0.100	+5.209	.001	.005	3	1
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	1
SKIN	GABRA6 →	+0.130	+4.684	<.001	.002	3	1
SKIN	CHRNB3 →	+0.006	+4.467	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

S100A7A by IFNGR1 expression — BLOOD_Lymphoma

Explore this box plot interactively →