IFNG

Across TCGA patient cohorts, IFNG mutation is significantly associated with the RNA expression of many other genes, with 414 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNG-associated genes across cancer lineages are RNA5SP536, RN7SKP92, and NOP53-AS1. Each is linked with IFNG in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNG-to-partner and partner-to-IFNG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP536 grouped by IFNG-low versus IFNG-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNG→partner) and Y-score (partner→IFNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP536 →	+0.494	+5.610	<.001	.004	3	2
BRCA	RN7SKP92 →	+0.647	+5.473	<.001	.005	3	2
UCEC	NOP53-AS1 →	+0.385	+3.210	.003	.009	3	2
BRCA	RNU6-421P →	+0.411	+6.064	<.001	.002	3	2
BRCA	SNORD31B →	+0.733	+5.070	<.001	.008	3	2
BRCA	MIR147A →	+0.894	+4.995	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 414 associations by consensus.

RNA5SP536 by IFNG expression — BRCA

Explore this box plot interactively →