IFNG

Across TCGA cell cohorts, IFNG mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFNG-associated genes across cancer lineages are NXF5, OR7D4, and OR13D1. Each is linked with IFNG in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNG-to-partner and partner-to-IFNG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXF5 grouped by IFNG-low versus IFNG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNG→partner) and Y-score (partner→IFNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NXF5 →	+0.027	+4.467	<.001	.004	3	1
LARGE_INTESTINE	OR7D4 →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR13D1 →	+0.031	+4.467	.001	.004	3	1
LARGE_INTESTINE	TBC1D3 →	+0.080	+4.273	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF27 →	+0.005	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

NXF5 by IFNG expression — LARGE_INTESTINE

Explore this box plot interactively →