Across TCGA patient cohorts, IFNE mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNE-associated genes across cancer lineages are A-Raf_pS299, JNK_pT183_Y185, and p62 Lck ligand. Each is linked with IFNE in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNE-to-partner and partner-to-IFNE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNE→partner) and Y-score (partner→IFNE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.157	-3.584	.006	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.174	-2.446	.033	.020	3	1
UCEC	p62 Lck ligand →	+0.455	+2.179	.003	.034	3	1
UCEC	PRDX1 →	+0.284	+2.999	.004	.035	3	1
UCEC	Annexin-1 →	+0.815	+3.189	.001	.010	3	1
UCEC	STAT3_pY705 →	-0.590	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

IFNE survival (RNA) · tumor vs normal (RNA) · all IFNE data types