Across TCGA pan-cancer cohorts, IFNE RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IFNE’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IFNE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFNE is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.
HNSC, THCA, and COAD are the cancer types where IFNE tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFNE RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.