IFNA8

Across TCGA patient cohorts, IFNA8 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNA8-associated genes across cancer lineages are JNK_pT183_Y185, JNK2, and Ku80. Each is linked with IFNA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNA8-to-partner and partner-to-IFNA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by IFNA8-low versus IFNA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNA8→partner) and Y-score (partner→IFNA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.185	-2.209	.009	.011	3	1
UCEC	JNK2 →	+0.203	+2.331	.016	.019	3	1
UCEC	Ku80 →	+0.229	+2.235	.022	.006	3	1
UCEC	MEK1 →	+0.485	+3.807	.001	<.001	3	1
UCEC	p70-S6K_pT389 →	-0.165	-1.700	.040	.044	3	1
UCEC	Paxillin →	+0.245	+2.469	.025	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

JNK_pT183_Y185 by IFNA8 expression — UCEC

Explore this box plot interactively →