IFNA8

Across TCGA pan-cancer cohorts, IFNA8 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IFNA8’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where IFNA8 RNA is repressed in tumor relative to normal tissue. In most cancer types IFNA8 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA, HNSC, and THCA are the cancer types where IFNA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFNA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.048	<.001	6	view →
HNSC	Male	II,III,IV	+0.015	.013	4	view →
THCA	Female	All	+0.049	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IFNA8–BRCA

Open the BRCA breakdown →