IFNA4

Across TCGA pan-cancer cohorts, IFNA4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IFNA4 data layer compared with 9 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IFNA4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IFNA4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and COAD show a favorable association.

LUSC, HNSC, and SKCM are the cancer types where IFNA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	III,IV	0.112	0.664	.003	9	view →
HNSC	OS	Median	III,IV	0.543	0.726	.021	6	view →
SKCM	DFS	Median	III,IV	1.000	0.467	.027	6	view →
COAD	OS	Median	II,III,IV	1.000	0.476	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IFNA4–LUSC (OS)

Open the LUSC breakdown →