IFNA21

Across TCGA patient cohorts, IFNA21 mutation is significantly associated with the RNA expression of many other genes, with 583 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNA21-associated genes across cancer lineages are LINC00709, MIR6864, and FBXO7. Each is linked with IFNA21 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFNA21-to-partner and partner-to-IFNA21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00709 grouped by IFNA21-low versus IFNA21-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNA21→partner) and Y-score (partner→IFNA21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC00709 →	+0.046	+4.212	<.001	.007	3	3
UCEC	MIR6864 →	+0.587	+2.224	.003	.008	3	2
UCEC	FBXO7 →	+0.486	+3.480	.005	.002	3	2
UCEC	EARS2 →	+0.533	+3.459	.003	.005	3	2
UCEC	OPA3 →	+0.432	+3.513	.004	.002	3	2
UCEC	RNU6-222P →	+0.417	+2.738	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 583 associations by consensus.

LINC00709 by IFNA21 expression — SKCM

Explore this box plot interactively →