IFNA21

Across TCGA pan-cancer cohorts, IFNA21 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated IFNA21 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IFNA21 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IFNA21 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

KIRP, SKCM, and HNSC are the cancer types where IFNA21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	IV	0.100	0.537	<.001	54	view →
SKCM	OS	Tertile	All	0.418	0.319	.007	33	view →
HNSC	OS	Tertile	All	0.846	0.730	.007	30	view →
PAAD	DFS	Tertile	All	0.623	0.288	.005	27	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	27	view →
THCA	OS	Tertile	II,III,IV	0.300	0.940	.001	25	view →
MESO	OS	Quartile	III,IV	0.772	0.507	.012	19	view →
BLCA	DFS	Tertile	IV	0.624	0.426	.013	18	view →
UVM	DFS	Tertile	All	0.285	0.769	.010	18	view →
LUAD	DFS	Quartile	IV	0.484	0.936	.002	18	view →
OV	OS	Tertile	II,III,IV	0.781	0.857	.033	12	view →
PCPG	DFS	Median	All	0.948	0.824	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

IFNA21–KIRP (DFS)

Open the KIRP breakdown →