IFNA17

Across TCGA patient cohorts, IFNA17 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNA17-associated genes across cancer lineages are p27_pT198, Paxillin, and ERK2. Each is linked with IFNA17 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNA17-to-partner and partner-to-IFNA17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by IFNA17-low versus IFNA17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNA17→partner) and Y-score (partner→IFNA17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.105	+2.459	.042	.020	3	2
UCEC	Paxillin →	+0.399	+3.179	.001	.010	3	2
UCEC	ERK2 →	+0.306	+2.459	<.001	.020	3	1
UCEC	JNK2 →	+0.276	+3.179	.003	.010	3	1
UCEC	PCNA →	+0.262	+2.459	.012	.020	3	1
UCEC	S6 →	-0.292	-3.169	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

p27_pT198 by IFNA17 expression — UCEC

Explore this box plot interactively →