IFNA16

Across TCGA pan-cancer cohorts, IFNA16 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated IFNA16 data layer compared with 4 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher IFNA16 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IFNA16 expression acts as an unfavorable survival marker.

SCLC, UCEC, and THYM are the cancer types where IFNA16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	All	0.055	0.708	<.001	36	view →
UCEC	OS	Tertile	All	0.126	0.681	<.001	36	view →
THYM	DFS	Tertile	All	0.123	0.871	<.001	36	view →
LGG	DFS	Tertile	All	0.380	0.849	<.001	27	view →
HNSC	DFS	Tertile	All	0.254	0.606	.011	27	view →
STAD	DFS	Tertile	All	0.479	0.668	.010	15	view →
SARC	DFS	Tertile	All	0.095	0.632	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IFNA16–SCLC (OS)

Open the SCLC breakdown →