Across TCGA pan-cancer cohorts, IFNA1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IFNA1 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IFNA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IFNA1 expression acts as an unfavorable survival marker.

LUSC, SARC, and PRAD are the cancer types where IFNA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.181	0.762	.027	12	view →
SARC	DFS	Median	All	0.006	0.611	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IFNA1 tumor-vs-normal RNA expression · all IFNA1 data types