Across TCGA pan-cancer cohorts, IFNA1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IFNA1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IFNA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFNA1 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

HNSC, THCA, and KIRP are the cancer types where IFNA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFNA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.146	<.001	6	view →
THCA	All	All	+0.149	.001	4	view →
KIRP	All	All	+0.110	<.001	4	view →
PRAD	All	All	−0.024	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IFNA1 RNA expression & survival · all IFNA1 data types