IFITM3P6

Across TCGA pan-cancer cohorts, IFITM3P6 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IFITM3P6 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IFITM3P6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IFITM3P6 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and LUAD are the cancer types where IFITM3P6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.439	0.256	<.001	137	view →
HNSC	DFS	Median	All	0.388	0.254	<.001	131	view →
LUAD	DFS	Median	All	0.842	0.737	<.001	103	view →
CESC	OS	Median	All	0.869	0.716	<.001	74	view →
KIRC	OS	Tertile	All	0.554	0.707	.002	42	view →
CHOL	DFS	Median	All	0.603	0.203	.001	29	view →
BRCA	DFS	Tertile	All	0.644	0.438	.003	28	view →
SARC	OS	Quartile	All	0.654	0.409	.004	13	view →
BLCA	OS	Tertile	All	0.737	0.601	.009	12	view →
LGG	DFS	Tertile	All	0.338	0.449	.014	10	view →
LIHC	OS	Median	III,IV	0.833	0.557	.012	9	view →
COAD	OS	Median	All	0.534	0.694	.029	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IFITM3P6–SKCM (OS)

Open the SKCM breakdown →