IFITM3P6

Across TCGA pan-cancer cohorts, IFITM3P6 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IFITM3P6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IFITM3P6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFITM3P6 is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and LUSC are the cancer types where IFITM3P6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFITM3P6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.048	<.001	12	view →
HNSC	All	III,IV	+0.449	<.001	11	view →
LUSC	Male	III,IV	−1.332	<.001	8	view →
UCEC	All	All	−0.353	.005	4	view →
CHOL	All	All	+0.589	.015	2	view →
LUAD	Female	III,IV	−0.554	.002	2	view →
KIRP	All	All	+0.347	.005	2	view →
ESCA	All	All	+0.736	.028	1	view →
THCA	All	IV	+0.582	.042	1	view →
COAD	All	All	−0.222	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IFITM3P6–KIRC

Open the KIRC breakdown →