IFIT3

Across TCGA pan-cancer cohorts, IFIT3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IFIT3 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IFIT3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IFIT3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD and LSCC are the cancer types where IFIT3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.911	1.000	.012	48	view →
LSCC	DFS	Median	All	0.894	0.477	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IFIT3–COAD (DFS)

Open the COAD breakdown →