IFIT3

Across TCGA patient cohorts, IFIT3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFIT3-associated genes across cancer lineages are EGFR, ERK2, and JNK2. Each is linked with IFIT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFIT3-to-partner and partner-to-IFIT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by IFIT3-low versus IFIT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIT3→partner) and Y-score (partner→IFIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.248	-3.000	<.001	.036	3	1
UCEC	ERK2 →	+0.265	+2.321	.003	.034	3	1
UCEC	JNK2 →	+0.333	+3.179	<.001	.010	3	1
UCEC	Ku80 →	+0.299	+2.598	.006	.006	3	1
UCEC	MEK1 →	+0.363	+2.584	.033	.011	3	1
UCEC	p21 →	+0.239	+2.584	.007	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

EGFR by IFIT3 expression — UCEC

Explore this box plot interactively →