IFIT3

Across TCGA cell cohorts, IFIT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,180 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IFIT3-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, Negative regulation of viral genome replication, and Defense response to virus. Each is linked with IFIT3 in more than 18 cancer types. Because this analysis shows association rather than direction, both IFIT3-to-partner and partner-to-IFIT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic pattern recognition receptor signaling pathway grouped by IFIT3-low versus IFIT3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIT3→partner) and Y-score (partner→IFIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cytoplasmic pattern recognition receptor signaling pathway →	+0.081	+1.748	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral genome replication →	+0.228	+3.143	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.108	+3.297	<.001	<.001	3	18
KIDNEY	Antiviral innate immune response →	+0.110	+2.493	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of viral life cycle →	+0.151	+2.913	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Pattern recognition receptor signaling pathway →	+0.079	+3.272	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,180 associations by consensus.

Cytoplasmic pattern recognition receptor signaling pathway by IFIT3 expression — LUNG_SCLC

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