IFIT2

Across TCGA patient cohorts, IFIT2 mutation is significantly associated with the RNA expression of many other genes, with 1,674 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFIT2-associated genes across cancer lineages are RNA5SP417, CRLF3P2, and KRTAP12-2. Each is linked with IFIT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFIT2-to-partner and partner-to-IFIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP417 grouped by IFIT2-low versus IFIT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIT2→partner) and Y-score (partner→IFIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP417 →	+0.597	+2.351	<.001	.001	3	3
BLCA	CRLF3P2 →	+0.040	+5.147	<.001	.003	3	2
CESC	KRTAP12-2 →	+0.085	+6.837	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.516	+1.967	<.001	.005	3	2
HNSC	RAB9BP1 →	+0.065	+5.822	<.001	.003	3	2
LUSC	RNU6-499P →	+0.257	+7.924	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,674 associations by consensus.

RNA5SP417 by IFIT2 expression — UCEC

Explore this box plot interactively →