Across TCGA pan-cancer cohorts, IFIT1B RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IFIT1B’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where IFIT1B RNA is repressed in tumor relative to normal tissue. In most cancer types IFIT1B is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.
LUSC, KICH, and KIRC are the cancer types where IFIT1B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFIT1B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.