Across TCGA cell cohorts, IFIT1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFIT1-associated genes across cancer lineages are CTXND2, SSMEM1, and MMP26. Each is linked with IFIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFIT1-to-partner and partner-to-IFIT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIT1→partner) and Y-score (partner→IFIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CTXND2 →	+0.140	+5.000	<.001	.005	3	1
LARGE_INTESTINE	SSMEM1 →	+0.021	+4.029	.007	.002	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	TBC1D3 →	+0.086	+5.009	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

IFIT1 survival (RNA) · tumor vs normal (RNA) · all IFIT1 data types