IFIH1

Across TCGA patient cohorts, IFIH1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,500 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IFIH1-associated genes across cancer lineages are DDX58, NMI, and PARP9. Each is linked with IFIH1 in more than 9 cancer types. Because this analysis shows association rather than direction, both IFIH1-to-partner and partner-to-IFIH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IFIH1 versus DDX58 in HNSC, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIH1→partner) and Y-score (partner→IFIH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DDX58 →	+1.497	+0.854	<.001	<.001	3	10
UCEC	NMI →	+0.826	+0.538	<.001	<.001	3	10
COAD	PARP9 →	+0.926	+0.449	<.001	<.001	3	10
HNSC	HERC6 →	+1.573	+0.833	<.001	<.001	3	9
BRCA	ETV7 →	+1.602	+0.770	<.001	<.001	3	9
GBM	OAS2 →	+1.543	+0.609	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,500 associations by consensus.

IFIH1 vs DDX58 — HNSC

Explore this scatter interactively →