IFIH1

Across TCGA patient cohorts, IFIH1 mutation is significantly associated with the RNA expression of many other genes, with 3,205 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFIH1-associated genes across cancer lineages are RCC1, WDHD1, and DHFR. Each is linked with IFIH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFIH1-to-partner and partner-to-IFIH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCC1 grouped by IFIH1-low versus IFIH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIH1→partner) and Y-score (partner→IFIH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCC1 →	+0.473	+3.711	.003	<.001	3	3
UCEC	WDHD1 →	+0.814	+4.480	<.001	<.001	3	3
UCEC	DHFR →	+0.638	+2.906	.001	.001	3	3
UCEC	C12orf43 →	+0.273	+2.747	.004	<.001	3	3
UCEC	CHAF1B →	+0.729	+2.736	<.001	<.001	3	3
UCEC	MED27 →	+0.411	+2.801	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,205 associations by consensus.

RCC1 by IFIH1 expression — UCEC

Explore this box plot interactively →