IFI6

Across TCGA cell cohorts, IFI6 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFI6-associated genes across cancer lineages are ELOA3DP, IQCF5, and TBC1D3. Each is linked with IFI6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI6-to-partner and partner-to-IFI6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by IFI6-low versus IFI6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI6→partner) and Y-score (partner→IFI6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3DP →	+0.031	+4.273	<.001	.006	3	1
LARGE_INTESTINE	IQCF5 →	+0.037	+5.022	<.001	.002	3	1
LARGE_INTESTINE	TBC1D3 →	+0.091	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ELOA3DP by IFI6 expression — LARGE_INTESTINE

Explore this box plot interactively →