IFI44L

Across TCGA patient cohorts, IFI44L mutation is significantly associated with the RNA expression of many other genes, with 958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFI44L-associated genes across cancer lineages are SKA1, HSBP1L1, and CXXC1. Each is linked with IFI44L in more than 2 cancer types. Because this analysis shows association rather than direction, both IFI44L-to-partner and partner-to-IFI44L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by IFI44L-low versus IFI44L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI44L→partner) and Y-score (partner→IFI44L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.464	+1.950	.009	.002	3	3
UCEC	HSBP1L1 →	+0.493	+3.818	<.001	<.001	3	3
UCEC	CXXC1 →	+0.320	+2.807	.006	.003	3	2
UCEC	PKN3 →	+0.548	+2.839	.001	.001	3	2
UCEC	CTLA4 →	+0.720	+3.711	<.001	<.001	3	2
UCEC	ICOS →	+0.646	+1.960	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 958 associations by consensus.

SKA1 by IFI44L expression — UCEC

Explore this box plot interactively →