IFI44L

Across TCGA pan-cancer cohorts, IFI44L RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IFI44L data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IFI44L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IFI44L expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

KIRP, SKCM, and UCEC are the cancer types where IFI44L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.784	0.917	<.001	99	view →
SKCM	OS	Median	All	0.410	0.266	<.001	98	view →
UCEC	DFS	Tertile	All	0.777	0.888	<.001	68	view →
KIRC	DFS	Quartile	III,IV	0.664	0.269	<.001	52	view →
UVM	DFS	Tertile	All	0.288	0.625	.003	41	view →
CESC	OS	Tertile	IV	0.607	0.202	.004	30	view →
CHOL	DFS	Quartile	II,III,IV	0.754	0.138	.004	29	view →
LGG	OS	Quartile	All	0.304	0.533	<.001	27	view →
PAAD	OS	Quartile	All	0.502	0.696	.005	27	view →
LUSC	DFS	Median	II,III,IV	0.640	0.789	.002	26	view →
BLCA	DFS	Median	IV	0.330	0.102	.006	22	view →
HNSC	OS	Tertile	III,IV	0.545	0.858	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IFI44L–KIRP (DFS)

Open the KIRP breakdown →