IFI44L

Across TCGA patient cohorts, IFI44L mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFI44L-associated genes across cancer lineages are MSH6, Fibronectin, and JNK2. Each is linked with IFI44L in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI44L-to-partner and partner-to-IFI44L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by IFI44L-low versus IFI44L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI44L→partner) and Y-score (partner→IFI44L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MSH6 →	+0.539	+2.832	.012	.035	3	2
UCEC	Fibronectin →	-0.307	-2.105	.015	.017	3	2
UCEC	JNK2 →	+0.215	+1.678	.004	.023	3	2
UCEC	PKC-delta_pS664 →	-0.110	-2.321	.017	.033	3	2
UCEC	TIGAR →	+0.147	+2.115	.012	.017	3	2
UCEC	c-Met_pY1235 →	+0.059	+2.087	.036	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MSH6 by IFI44L expression — COAD

Explore this box plot interactively →