IFI44L

Across TCGA cell cohorts, IFI44L RNA expression is significantly associated with the go_rna of many other GO terms, with 3,638 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IFI44L-associated GO terms across cancer lineages are Cellular response to exogenous dsRNA, CD8-positive, alpha-beta T cell activation, and Negative regulation of immune response. Each is linked with IFI44L in more than 14 cancer types. Because this analysis shows association rather than direction, both IFI44L-to-partner and partner-to-IFI44L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to exogenous dsRNA grouped by IFI44L-low versus IFI44L-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI44L→partner) and Y-score (partner→IFI44L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cellular response to exogenous dsRNA →	+0.192	+3.579	<.001	<.001	3	15
BREAST	CD8-positive, alpha-beta T cell activation →	+0.149	+1.619	<.001	<.001	3	15
BREAST	Negative regulation of immune response →	+0.098	+2.099	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.098	+3.656	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Antiviral innate immune response →	+0.097	+3.366	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Interferon-mediated signaling pathway →	+0.152	+2.755	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,638 associations by consensus.

Cellular response to exogenous dsRNA by IFI44L expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →