IFI44

Across TCGA pan-cancer cohorts, IFI44 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IFI44 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IFI44 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated IFI44 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, OV, and BLCA are the cancer types where IFI44 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.928	0.433	.014	20	view →
OV	DFS	Median	All	0.104	0.541	<.001	18	view →
BLCA	DFS	Median	III,IV	0.122	0.572	.004	15	view →
ESCA	OS	Median	All	0.198	0.872	.003	12	view →
LUAD	DFS	Median	II,III,IV	1.000	0.399	.027	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IFI44–UCEC (DFS)

Open the UCEC breakdown →