IFI27L1

Across TCGA patient cohorts, IFI27L1 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IFI27L1-associated genes across cancer lineages are ZNF705D, RNA5SP146, and RNU6-468P. Each is linked with IFI27L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI27L1-to-partner and partner-to-IFI27L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF705D grouped by IFI27L1-low versus IFI27L1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI27L1→partner) and Y-score (partner→IFI27L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF705D →	+0.077	+5.182	<.001	.007	3	2
HNSC	RNA5SP146 →	+0.389	+5.124	<.001	.008	3	2
LUAD	RNU6-468P →	+0.398	+5.279	<.001	.006	3	2
HNSC	MTCO3P17 →	+0.117	+5.182	<.001	.007	3	2
UCEC	PSMB7P1 →	+0.112	+3.747	<.001	.003	3	2
BLCA	RNU6-993P →	+0.386	+6.147	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

ZNF705D by IFI27L1 expression — HNSC

Explore this box plot interactively →