IFI27L1

Across TCGA pan-cancer cohorts, IFI27L1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IFI27L1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where IFI27L1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IFI27L1 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LIHC, HNSC, and KIRP are the cancer types where IFI27L1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFI27L1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+1.253	<.001	9	view →
HNSC	All	All	+0.523	<.001	9	view →
KIRP	All	II,III,IV	+0.658	<.001	8	view →
LUAD	Female	II,III,IV	−0.612	<.001	7	view →
ESCA	All	All	+0.759	<.001	5	view →
KICH	All	All	−0.558	.003	5	view →
THCA	Male	II,III,IV	−0.497	.004	5	view →
CHOL	All	All	+1.194	<.001	4	view →
BLCA	All	All	+0.500	.016	4	view →
UCEC	All	All	+0.459	.040	2	view →
PAAD	Female	All	+0.405	.027	2	view →
PRAD	All	All	+0.312	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IFI27L1–LIHC

Open the LIHC breakdown →