IFI27L1

Across TCGA cell cohorts, IFI27L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,324 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IFI27L1-associated GO terms across cancer lineages are Regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway, Negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway, and rRNA metabolic process. Each is linked with IFI27L1 in more than 7 cancer types. Because this analysis shows association rather than direction, both IFI27L1-to-partner and partner-to-IFI27L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway grouped by IFI27L1-low versus IFI27L1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI27L1→partner) and Y-score (partner→IFI27L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway →	+0.075	+0.732	.001	.008	3	8
BREAST	Negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway →	+0.075	+0.732	.001	.008	3	8
SOFT_TISSUE	rRNA metabolic process →	-0.088	-0.714	<.001	<.001	3	8
SKIN	Positive regulation of RNA export from nucleus →	-0.068	-0.614	<.001	<.001	3	7
SOFT_TISSUE	Positive regulation of transcription by RNA polymerase I →	-0.084	-0.566	<.001	.001	3	7
LUNG_SCLC	Ribosomal small subunit biogenesis →	-0.094	-1.009	<.001	.002	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,324 associations by consensus.

Regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway by IFI27L1 expression — BREAST

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