IFFO1

Across TCGA patient cohorts, IFFO1 mutation is significantly associated with the RNA expression of many other genes, with 2,145 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFFO1-associated genes across cancer lineages are RNA5SP222, CCL3, and SENP3-EIF4A1. Each is linked with IFFO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFFO1-to-partner and partner-to-IFFO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP222 grouped by IFFO1-low versus IFFO1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFFO1→partner) and Y-score (partner→IFFO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP222 →	+0.286	+7.731	<.001	.009	3	2
UCEC	CCL3 →	+1.041	+3.119	<.001	<.001	3	2
UCEC	SENP3-EIF4A1 →	+0.111	+3.558	.001	.002	3	2
HNSC	RNASE12 →	+0.101	+7.132	<.001	<.001	3	2
HNSC	MIR4305 →	+0.377	+5.069	<.001	.008	3	2
LUSC	M6PRP1 →	+0.063	+4.922	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,145 associations by consensus.

RNA5SP222 by IFFO1 expression — BRCA

Explore this box plot interactively →