Across TCGA cell cohorts, IER5L mutation is significantly associated with the mutation status of many other genes, with 1,043 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IER5L-associated genes across cancer lineages are PACS1, INPP5D, and NDST2. Each is linked with IER5L in more than 3 cancer types. Because this analysis shows association rather than direction, both IER5L-to-partner and partner-to-IER5L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IER5L→partner) and Y-score (partner→IER5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PACS1 →	+5.014	+5.584	.003	.003	1	4
BLOOD_Lymphoma	INPP5D →	+4.429	+5.247	.005	.005	1	3
BLOOD_Lymphoma	NDST2 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	PRDM10 →	+4.429	+5.247	.005	.005	1	3
BLOOD_Leukemia	RGS11 →	+4.285	+4.285	.001	.001	1	3
BLOOD_Leukemia	SMARCA2 →	+3.063	+3.498	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,043 associations by consensus.

Exploration

IER5L survival (RNA) · tumor vs normal (RNA) · all IER5L data types