IER2

Across TCGA cell cohorts, IER2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,417 significant associations in total. CNS shows the largest number of these associations.

The most reproducible IER2-associated GO terms across cancer lineages are Response to interleukin-8, Cellular response to interleukin-8, and Circadian temperature homeostasis. Each is linked with IER2 in more than 18 cancer types. Because this analysis shows association rather than direction, both IER2-to-partner and partner-to-IER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to interleukin-8 grouped by IER2-low versus IER2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IER2→partner) and Y-score (partner→IER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Response to interleukin-8 →	+1.235	+1.683	<.001	<.001	3	19
BREAST	Cellular response to interleukin-8 →	+1.235	+1.683	<.001	<.001	3	19
KIDNEY	Circadian temperature homeostasis →	+1.211	+1.195	<.001	<.001	3	16
BLOOD_Leukemia	Response to heparin →	+1.327	+1.091	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Cellular response to heparin →	+1.100	+1.242	.009	.002	2	16
URINARY_TRACT	Response to forskolin →	+0.186	+1.561	.001	.003	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,417 associations by consensus.

Response to interleukin-8 by IER2 expression — BREAST

Explore this box plot interactively →