IDS

Across TCGA pan-cancer cohorts, IDS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IDS data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher IDS mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IDS expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

LSCC, GBM, and LUAD are the cancer types where IDS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.473	0.941	.004	41	view →
GBM	DFS	Median	All	0.456	0.288	.003	11	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	9	view →
CCRCC	OS	Tertile	IV	0.961	0.174	.036	6	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IDS–LSCC (OS)

Open the LSCC breakdown →