IDS

Across TCGA pan-cancer cohorts, IDS RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IDS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IDS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IDS is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where IDS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IDS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.388	<.001	11	view →
KIRC	Male	All	+0.654	<.001	11	view →
LUSC	Female	II,III,IV	−1.257	<.001	7	view →
UCEC	All	All	−1.297	<.001	6	view →
CHOL	Female	All	+2.063	<.001	5	view →
COAD	Female	II,III,IV	−0.779	<.001	5	view →
PAAD	Male	All	+0.750	.008	4	view →
BLCA	Male	All	−0.740	.006	4	view →
THCA	Male	All	+0.325	.030	3	view →
PRAD	All	All	−0.391	<.001	2	view →
BRCA	Female	All	−0.173	.021	2	view →
LIHC	All	All	+0.286	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IDS–HNSC

Open the HNSC breakdown →