IDS

Across TCGA patient cohorts, IDS mutation is significantly associated with the RNA expression of many other genes, with 5,522 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDS-associated genes across cancer lineages are RN7SL134P, ATP5F1A, and NIPA1. Each is linked with IDS in more than 2 cancer types. Because this analysis shows association rather than direction, both IDS-to-partner and partner-to-IDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by IDS-low versus IDS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDS→partner) and Y-score (partner→IDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL134P →	+0.143	+3.789	<.001	.004	3	3
UCEC	ATP5F1A →	+0.421	+1.818	<.001	<.001	3	3
UCEC	NIPA1 →	+0.917	+2.462	<.001	<.001	3	3
UCEC	C16orf91 →	+0.532	+2.462	<.001	<.001	3	3
UCEC	TFB1M →	+0.345	+1.470	<.001	<.001	3	3
UCEC	RNF126 →	+0.501	+1.839	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,522 associations by consensus.

RN7SL134P by IDS expression — COAD

Explore this box plot interactively →